Chloride sodium cyanide iodine willow amine
Closantel Sodium
CAS: 61438-64-0
Molecular Formula: C22H13Cl2I2N2NaO2
Chloride sodium cyanide iodine willow amine - Names and Identifiers
| Name | Closantel Sodium |
| Synonyms | CLOSANTEL(NA) Closan Sodium Closantel Sodium CLOSANTEL SODIUM closantel sodium salt Closan Sodium (Patented) Closantel Sodium (Patented) Chloride sodium cyanide iodine willow amine Sodium N-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-o-tolyl)-2-hydroxy-3,5-diiodobenzamidate n-[5-chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid sodium salt sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-4,6-diiodophenolate sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-1-hydroxy-4,6-diiodocyclohexa-2,4-diene-1-carboxylate sodium 2-[[5-chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylanilino]-oxomethyl]-1-hydroxy-4,6-diiodo-1-cyclohexa-2,4-dienecarboxylate |
| CAS | 61438-64-0 |
| EINECS | 262-794-7 |
| InChI | InChI=1/C22H14Cl2I2N2O2.Na/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29;/h2-9,17,29H,1H3,(H,28,30);/q;+1/p-1 |
Chloride sodium cyanide iodine willow amine - Physico-chemical Properties
| Molecular Formula | C22H13Cl2I2N2NaO2 |
| Molar Mass | 685.06 |
| Melting Point | >230°C (dec.) |
| Boling Point | 590.5°C at 760 mmHg |
| Flash Point | 310.9°C |
| Vapor Presure | 1.53E-14mmHg at 25°C |
| Appearance | Solid |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| MDL | MFCD03427328 |
| Use | Used as an antiparasitic agent |
| In vitro study | Closantel inhibited drug-resistant Staphylococcus aureus and Enterococcus faecium, MICs 1 μg/mL and 1 μg/mL, respectively. The MRSA MICs inhibited by Closantel was 2 μg/mL. Closantel completely blocks the infection of host cells by E. chaffeensis or A. phagocytophilum, treating in A dose-dependent manner cells persistently infected for one day, thereby clearing the infection. Closantel inhibits the activity of three sensor kinase autokinases from E. chaffeensis. Closantel (50 μg/mL) acts on vascular tissue to induce contractions of greater amplitude and higher frequency than normal. Stimulation at such amplitude and frequency for about 15 minutes is accompanied by an increase in muscle tension, this results in a maximum of 16 min, which is a level greater than 1.5 times the maximum normal amplitude. |
| In vivo study | Closantel (10 mg/kg) acted on 25 F before administration. Mice with posterior metacercaria of the hepatica family, after 24 hours, cause total surface damage in mice in the form of erosion of the anterior and posterior limbs of the fluke and extensive molting on the back and abdominal surfaces. Closantel (7.5 mg/kg) in combination with a broad-spectrum anthelmintic was very effective against the nematode twister, but not very effective against the genus Strongylus in sheep. Closantel significantly reduced isotope levels in closantel-resistant, adult sheep infected with the twisted blood spear nematode. |
Chloride sodium cyanide iodine willow amine - Risk and Safety
| HS Code | 29269090 |
Chloride sodium cyanide iodine willow amine - Reference Information
| anti-parasitic drugs | , it belongs to the same salicylanilide compound as the iodoethers, and is a new broad-spectrum antiparasitic drug currently used in the aquaculture industry, with the appearance of yellowish powder, odorless or slightly odorous, soluble in ethanol or acetone, soluble in methanol, insoluble in water or in chloroform. The pharmacological effect is to inhibit the phosphorylation process of the mitochondria of the worm, thus preventing the synthesis of adenosine triphosphate (ATP) in the worm, resulting in the rapid weakening of the energy metabolism of the worm and finally dying. Sodium chlorothionamide can completely kill the scabies, blood lice, roundworm, class round nematode, kidney nematode, whipworm, cattle carboxy nematode, supine nematode, radiation esophageal nematode, large flukes, fasciola hepatica, capillary nematode, skin fly maggot, sheep nose fly maggot, tick fly, scabies mite, nematode, Fasciola, horse stomach fly, dog fat mite and other poultry internal and external parasites. For a variety of flukes, nematodes and arthropod larvae have good curative effect; Its anti-flukes repellent activity is mainly aimed at Fasciola hepatica, the larval repellent activity against nematodes and arthropods is mainly directed against various blood-or plasma-sucking worms. Clinical efficacy tests showed that, when administered at a dose of 10mg/kg body weight, the sheep Fasciola hepatica, before and after the disc flukes, pulmonary filariasis and most of the digestive tract nematodes in vitro and in vivo have a complete repellent effect, is the best dose of sheep anthelmintic.|
| biological activity | Closantel Sodium is a Gram-positive antibacterial activity inhibitor, which inhibits the Gina/spoof system, the IC50 was 3.8 μm. |
| Use | used as an antiparasitic drug , gastrointestinal nematodes and arthropod larval stage have repellent activity. Mainly used for the prevention and treatment of cattle, sheep Fasciola, gastrointestinal nematode disease and sheep manic myiasis, such as |
Last Update：2024-04-09 21:04:16
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